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Necessity of Research

International·Domestic Research Trend and Prospect

  • Although various analysis systems such as CT, MRI, SPECT, PET have been used to observe and analyze changes in bloodstream of the body, cell migration and neural activity, there exist disadvantages that these systems can apply only specific medical facilities
  • The bio-imaging system, one of the newest ubiquitous health systems, is that implant micromini bio-imaging system in the body, wirelessly connect to its signal, and then analyze ex vivo. Various types of bio-imaging systems have been developing in international groups, there is no example developed by domestic groups.
  • The development of successful bio-imaging system is dependent on development of multifunctional nanobio-interface materials for detecting biological components as target analytes meaning small, cheap, and highly efficient analysis device instead of well-trained people working on examination department in medical facilities
  • The hyperfine needle array as a biosensor platform is one of representative devices using micro-fabrication technology. It can inject drugs in the body or extract specific components from the body. Moreover, it is possible to study brain function as inject hyperfine needle into human brain and detect/sent out the signals. However, this hyperfine needle can easily break by exterior force and there is the possibility to remain in the body.
  • In order to fabricate biocompatible hyperfine needle, it is necessary to use biocompatible and highly soft polymers. It will be studied as easily wearable patch-type with large surface. Moreover, micro-fluidic device will be integrated with hyperfine needle array. It will inject certain quantity of drugs through a wireless signal on time when it needs to dose drugs. In addition, biological information of the body can be extracted by integrated hyperfine needle array into biosensor.

Necessity of International Collaboration

  • In order to establish the research direction as mentioned above, it is necessary to collaborate with researchers of various fields. Moreover, it is very important to secure source of technology and derivative technology of this field in an early stage through formation of research clusters.
  • Dr. Kamal Alameh at Edith Cowan Univ. has extensive experiences in design essential derive circuit and optical signal processing related to this project such as microphotonic RF signal processor, OPTO-VLSI processor.
  • In order to improve signal to noise and measuring stability of interface between nanobio- interface materials which are surface-treated on the fabricated biosensor device, the properties of micro-surface should be measured. The formation of optimized interface will be accomplished by collaboration with researchers worked in Nano/Bio specialized fields in Prof. Harald Fuchs group (University of Muenster, Center for Nanotechnology, CeNTech).

Final Objective

Development of ULSI (ultra large scale integration) implantable imaging sensor and high-sensitive nanobio-sensor using hyperfine needle array

 

A) Research Objective of Each Phase

Research Objective of Each Phase
Division Objective of Research Development
1st phase
  • Development of Nanobio material and specialized analysis
  • Development fabrication process of hyperfine needle using biocompatible nanobio materials
  • Establishment of fabrication technique of optical system using computer simulation
2nd phase
  • Study on interface compatibility between developed nenobio-interfaces and electrodes of biosensor, optimization of their properties, and feedback
  • Fabrication of hyperfine needle using composites of biocompatible nanobio material and polymer
  • Design and fabrication of low power-consumption, single array VCSEL and high efficiency PD array
3rd phase
  • Optimization of biosensor with developed nanobio-interfaces and application to bio-surface
  • Fabrication of highly soft, wearable patch-type hyperfine needle array
  • Fabrication of single-chip integration VCSEL and PD array and evaluation of their properties
4th phase
  • Collaboration study of biosensor applied nanobio-interfaces with other unit projects (Development of advanced biosensor for supplying and storing energy)
  • Fabrication of patch-type hyperfine needle array integrated into micro-fluidic device
  • Simulation of implantation of semiconductor integrating imaging sensor and evaluation of their properties
  • Fabrication of integrating system of multiplexer and digital signal processing
5th phase
  • Strategy plan for commercializing high-sensitive multifunctional nanobio- sensor and final evaluation
  • Fabrication of hyperfine needle array interlocked with biosensor
  • Fabrication of integrating system containing wireless communication, Simulation of evaluation of implanted imaging sensor

B. Research Contents of Each Phase

Research Contents of Each Phase
Division Research contents
1st phase
  • Development and specialization of nanobio material
  • Development of photolithography process using polymers
  • Design and fabrication of optimized optical system using Code-V and structure of array device
2nd phase
  • Study on interface compatibility and application nanobio material to biosensor
  • Fabrication of hyperfine needle array using nanobio-polymer composite
  • Fabrication/evaluation of low power consumption and single mode array, Fabrication/evaluation of high efficiency PD array
3rd phase
  • Optimization of nanobio-interfaces for applying biosensor and in vivo/in vitro test
  • Fabrication of patch-type hyperfine needle array using nanobio-polymer composite
  • Development of single chip integration technique of VCSEL and PD array and wavelength drift compensation technique
4th phase
  • Collaboration with other unit projects related to biosensor with nanobio-interfaces
  • Development of device with combination of hyperfine needle array and micro-fluidic device
  • Fabrication of structure for simulation of implantation, simulation of fabricated structure and evaluation of its properties
  • Establishment of integrating system of multiplexer and digital signal processing (collaboration with other projects)
5th phase
  • Strategy of commercializing high-sensitive multifunctional nanobio-sensor and final evaluation
  • Development of hyperfine needle array with combination of micro-fluidic device and biosensor
  • Fabrication of integrating system containing wireless communication (collaboration with other projects)
  • Simulation and evaluation of implantation of semiconductor integrated imaging sensor containing exterior communication

Strategy Method and Structure

There is a plan of collaboration with Prof. Herald Fuchs groups (University of Muenster, Center for Nanotechnology; CeNTech) regarding study on nanobio-interface materials based on functionalized CNTs, CDs, NPs, and biomolecules. Through this collaboration, optimized nanobio material will be obtained. Moreover, surface treatment method of biosensor electrode, low power comsumption signal processing, and more advanced high-sensitive multifunctional biosensor will be accomplished by the collaboration among hyperfine needle fabrication group, MEMS group, RF System group, and other participating groups.

The implantation bio-imaging system consists of 1) optical system containing VCSEL and PD array 2) circuit system with VCSEL driving circuit and PD receiving system 3) signal processing and wireless communication system. Prof. Yong Tak Lee and Prof. Kamal will be responsible for optical system and circuit system and the collaboration with Unit Project 6 will cover wireless communication and signal processing fields

Overview of Research Project and Structure of Researchers

Capability of Researchers and Structure

  • Prof. Kurt E. Geckeler has been studied CNTs-Proteins interactions as well as developed CD deivatives, especially, opened new research fields in CDs-Fullerene complex. He has predominant research experience and accomplishments such as papers, patents, and books regarding CNTs and CDs. Moreover he already published one of papers concerning polymer-base biosensor at 1993. In addition, his book, Advanced Macromolecular and Supramolecular Materials and Process published 2003 and Functional Nanomaterials published 2006 reflected his extensive knowledge such as supramolecular nanotechnology and nanomaterials, respectively.
  • Prof. Young Ha Kim is one of experts regarding tissue engineering, blood compatible, biodegradable, biomedical polymers, and environmentally degradable plastics. He has been published more than 100 SCI papers and 40 patents. Especially, he is world-famous scientist in biomaterials for diagnostics, analysis, and therapy. He was the President of The International Union of Societies for Biomaterials Science and Engineering (IUSBSE) for 4 years since 2004. Moreover, one of his research developments, biodegradable surgical suture is the third world development followed by USA and Japan. He commercialized it and has been exporting 100 billion won annually.
  • Prof. Jong Hyun Lee is an expert in optical/bio MEMS device and has been published several papers based on excellent research results since 8 years. He is committee of several domestic and international conferences.
  • Prof. Seong Yang has been studied micro-fluidic device and biomedical device. His group will collaborate with Prof. Geckeler group and will accomplish the final goal which is the development highly soft, wearable biosensor in conjunction with mechanical, electrical MEMS device and biosensor technique.
  • Prof. Yong Tak Lee is an expert in optical device, optical integrating circuite, and optical sensor system such as semiconductor laser (VCSEL, DFB-LD, Uncooled LD), photodetector (pin-PD, APD, RCE-PD). Especially, he has world-class research ability and know-how in single integration VCSEL and PD array which are essential to develop optical imaging system.
  • Prof. Kamal Alameh is an expert in mocrophotonic RF signal processor and OPTO-VLSI processor. He has extensive experience in design of derive circuit and optical signal processing which are the essential parts in this project.

Structure of International Collaboration

  • The Electron Science Research Institute (ESRI) at Edith Cowan Univ. has been developed microphonic system and optical/electrical signal processing technology. It is one of research institute having facilities and technology which GIST can access our own technique in future. This institute will play an important role in development and evaluation of optical-imaging integrating system.
1)Development of high-sensitive multifunctional nanobio sensor with combination of nanobio material and wearable patch-typed hyperfine needle array.

1st step: Development of optimized materials through synthesis of specialize biofincaionlized nanomaterials and fabrication process/technique of hyperfine needle using polymer

  • Development of biofunctionalized nanomaterials in conjunction with CNTs, CDs, NPs and biomolecules
  • Analysis and optimized design of developed biofunctionalized nanomaterials
  • Development of process/technique of hyperfine needle using polymer

2nd step: Study on interface compatability between nanobio-interface and hyperfine needle array and feedback

  • Development of biosensor based on combination of unit project groups (MEMS, hyperfine needle array)
  • Evaluation of stability and reliability of developed nanobio-interface materials located in sensor interface

3rd step: Collaboration between nanobio-interface team and other unit project groups

  • Establishment of advanced system based on the collaboration of energy research team
  • Establishment of advanced system of information technology through collaboration with information technology team
2) Development of implantable semiconductor integrated optical imaging sensor

1st step: Single chip integrated VCSEL/PD array

  • Design optimized optical system using computer simulation
  • Fabrication of low power consumption, single mode VCSEL and high efficiency PD array

2nd step: Development of integrating optical imaging system of driving and receiving circuit

  • Design of VCSEL driving circuit and PD receiving circuit
  • Design of power-minimized structure and design/fabrication of array-type driving/receiving circuit
  • Fabrication and evaluation of driving/receiving circuit-integrated optical imaging system

3rd step: Development of implantable semiconductor integrated optical imaging sensor containing exterior communication

  • Fabrication of integrating system containing wireless communication
  • Simulation and evaluation of implantation
1) Contribution to Development of Science and Technology

Although Korea has been actively studying nano-bio technology as well as several developed countries, there is no significant research regarding the research of combination of nanochemistry and supramolecular concept. Therefore we are expecting to simultaneously develop scientific technology composed of nanotechnology, biotechnology, nanochemistry, suprmolecular chemisty, medicinal chemistry as well as information technology.

Through optical imaging technology containing implantable exterior communication, it will be possible to analysis cellular activities, physiological, and chemical functions in daily life. Consequently, it will contribute to identify mechanism of neuroscience and cognitive science. In addition, it will make the basis of developing advanced sensors similar as electronic nose and electronic tongue.

2) Propagation Effect: Economical, Social, and Cultural

It will suggest new technology which current technology cannot solve, for example, real-time and mobile analysis method of neuro signal and detecting tumor cells.

Our technique will be applicable to prostheric arm using real-time analysis of neuro signal and mobile micro-fluidic sensing system and will be commercialized. Therefore we are expecting the economical propagation effect will be very effective.

This project will be helpful to extend research fields of nanobio-interface materials and develop high-sensitive multifunctional nanobiosensor which can simultaneously detect various analytes. In future, the commercialized products using our developed techniques will be one of the leaders in the world market.

The development of highly soft, wearable bio-device can generate low-price, high value –added products which the low-income groups can easily us. Therefore, we are expecting our technology will reduce the gap between the medical services.

 
 

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